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+are+having+transformative+impacts+across+a+wide+range+of+scientific+fields%252C+particularly+in+the+biomedical+sciences.+Just+as+the+goal+of+Natural+Language+Processing+is+to+understand+sequences+of+words%252C+a+major+objective+in+biology+is+to+understand+biological+sequences.+Genomic+Language+Models+(gLMs)%252C+which+are+LLMs+trained+on+DNA+sequences%252C+have+the+potential+to+significantly+advance+our+understanding+of+genomes+and+how+DNA+elements+at+various+scales+interact+to+give+rise+to+complex+functions.+To+showcase+this+potential%252C+we+highlight+key+applications+of+gLMs%252C+including+functional+constraint+prediction%252C+sequence+design%252C+and+transfer+learning.+Despite+notable+recent+progress%252C+however%252C+developing+effective+and+efficient+gLMs+presents+numerous+challenges%252C+especially+for+species+with+large%252C+complex+genomes.+Here%252C+we+discuss+major+considerations+for+developing+and+evaluating+gLMs.&cdnurl=https%3a%2f%2fth.bing.com%2fth%2fid%2fR.4e2a701ffc7d346a791e2601d2b9d0ff%3frik%3d8YJAP%252fcirUektQ%26pid%3dImgRaw%26r%3d0&exph=630&expw=1200&q=Genome+Language+Model&FORM=IRPRST&ck=C7407A93BCA57152D7D28A6934ADE56A&selectedIndex=17&itb=0)
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