In this collection, we highlight papers reporting structural insights into amyloid fibrils associated with neurodegenerative and systemic diseases as well as functional amyloids that were obtained ...

Researchers from the National Institutes of Natural Sciences and Nagoya City University have achieved a significant breakthrough by elucidating the structure of amyloid β (Aβ) bound to glycolipids on ...

Research into preventing and reversing the creation of misfolded protein aggregates known as fibrils could provide new therapeutic opportunities in the fight against neurodegenerative diseases such as ...

Amyloid-β is not the only component of the senile plaques that mark Alzheimer’s disease. Are the others mere bystanders that get caught in a web of Aβ fibrils, or are they more nefarious, instigating ...

For decades, the structures of repetitive, flexible folds of amyloid fibrils eluded X-ray crystallographers, but with the advent of cryo-electron microscopy, these elusive amyloids were no longer able ...

An experimental drug developed at Northwestern University has demonstrated further promise as an early intervention for Alzheimer's disease.

Scientists reversed advanced Alzheimer's in mice using a compound that restores cellular energy. The breakthrough challenges ...

Researchers have developed a microscopy technique to visualize amyloid beta’s underlying structure, which could yield new insights into Alzheimer’s disease. As the prevalence of Alzheimer’s rises, ...

The accumulation of amyloid fibrils causes heart failure, and patients suffer from fluid retention, fatigue, and arrhythmias. The disease can be caused by genetic mutations or related to aging.

Amyloid heart disease occurs when amyloid fibrils build up in the heart, making it more difficult for the heart to pump blood around the body. Eventually, this can lead to heart failure. People can ...

In a recent study posted to the bioRxiv preprint* server, researchers in Sweden investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein amyloid as a potential ...