ascopubs.org

Prevention of 5-FU-induced health-threatening toxicity by pretherapeutic DPD deficiency screening: Medical and economic assessment of a multiparametric approach.

A phase II, randomized, double blind comparison of calcium aluminosilicate clay (CASAD) versus placebo (dibasic calcium carbonate) for the prevention of diarrhea in patients (pts) with metastatic ...
ascopubs.org

DPD deficiency: Medicoeconomic evaluation of pretreatment screening of 5-FU toxicity.

Factors influencing the CEA positivity in patients with colon cancer including race. Background: Deficiency of DPD activity is associated with severe toxicity or even death after the first two cycles ...
Cure Today

What Patients With Cancer Should Know About DPD Deficiency Prior to Chemo

Dr. Gabriel A. Brooks discusses what DPD deficiency is and why it is important for patients with cancer receiving 5-FU or Xeloda to be aware of it. The Food and Drug Administration (FDA) has updated ...
Business Wire

Wellstat Investigational Drug Shows Life-Saving Potential in Treating Toxicity of Widely Used Cancer Chemotherapy

GAITHERSBURG, Md.--(BUSINESS WIRE)--Wellstat Therapeutics announced today that the company’s investigational drug uridine triacetate has further demonstrated its life-saving potential in treating ...
Medscape

Simple Way to Avoid Severe Toxicity From 5-FU and Related Drugs

July 5, 2012 — A simple screening process can identify people who will react badly to the fluoropyrimidine group of chemotherapy drugs, which includes 5-fluorouracil and the related oral products ...
Ärzteblatt

Therapie des metastasierten kolorektalen Karzinoms mit 5-FU/Folinsäure und Irinotecan: Gentest vor Gabe von 5-FU

In dem Artikel wird ausführlich auf die therapieinduzierte Toxizität bei der Verabreichung von 5-Fluorouracil (5-FU) eingegangen, die sich in ihrem Ausmaß bei den verschiedenen Therapieschemata ...
Medscape

First Chemo 'Antidote' Cuts Deaths From 5-FU Toxicity

SAN FRANCISCO — The first and only antidote for a chemotherapy overdose appears to be a safe and effective life-saving emergency treatment. The product, uridine triacetate (Vistogard, Wellstat ...
Nature

Prognostic significance of dihydropyrimidine dehydrogenase expression in breast cancer

We have investigated dihydropyrimidine dehydrogenase expression as a prognostic marker in breast cancer. A total of 119 women with breast cancer undergoing surgery between 1985 and 1996 were included ...
National Institute for Health and Care Excellence

Fluorouracil chemotherapy: The My5‑FU assay for guiding dose adjustment

The Committee recommended further research to validate the accuracy and precision of the My5‑FU assay for the quantitative determination of 5‑fluorouracil (5‑FU) at the lower end of its measuring ...
Nature

Evaluations of biomarkers associated with 5-FU sensitivity for non-small-cell lung cancer patients postoperatively treated with UFT

Lung cancer is one of the most common cancers and the major cause of cancer-related death in North America, Europe, and Japan (Cersosimo, 2002). Non-small-cell lung cancer (NSCLC) comprises about 75% ...
Ärzteblatt

Therapie des metastasierten kolorektalen Karzinoms mit 5-FU/Folinsäure und Irinotecan: Schlusswort

ren oder gar lebensbedrohlichen Nebenwirkungen einer 5-FU- beziehungweise Irinotecan-haltigen Chemotherapie bewahren. Die Häufigkeit eines kompletten oder partiellen DPD-Enzymmangels wird auf 0,1 ...