During embryonic development, the process of epithelial-mesenchymal transition (EMT) allows the migration of cells to different destinations to form organs and tissues. This same program is used by ...

Cancer's most insidious ability lies not just in its capacity to grow, but in its power to transform. When tumor cells undergo epithelial-to-mesenchymal transition (EMT), they shed their structured, ...

Ovarian cancer remains the leading cause of death among cancers affecting the female reproductive system, largely because current treatments are not effective once the cancer has spread (metastasised) ...

In vitro studies pinpoint signaling pathways that could be potential targets in oral squamous cell carcinoma treatments.

The regulation and remodeling of the tumor microenvironment (TME) are closely associated with how cancers typically progress and metastasize. The extracellular matrix (ECM) is an intricate network of ...

Fluorescent image of of a patient’s colorectal cancer liver metastasis showing the diversity of cell states from normal intestinal states (dark blue) to atypical cell states (other colors). Image ...

A recent study published in Engineering has shed new light on the mechanisms underlying the metastasis of head and neck squamous cell carcinoma (HNSCC). The research identified enolase 2 (ENO2), a ...

Deaths from cancer have fallen dramatically. They’ve dropped by 34% over the past three decades — largely thanks to better treatments, earlier detection, and fewer people smoking. But cancer ...

Metastasis is responsible for 90 percent of cancer deaths. Researchers have found that the mutations driving it may stem from a commonly inherited variant of the PCSK9 gene. Metastasis is responsible ...