Understanding how these functions impact a given compound is essential for effective preclinical drug development. Hepatocytes comprise approximately 80 % of the liver’s volume but only represent ...

Liver cells exposed to a high fat diet revert to an immature state that is more susceptible to cancer-causing mutations.

Bone marrow contains stem cells with the potential to differentiate into mature cells of various organs. We determined whether circulating stem cells have a similar potential. Biopsy specimens from ...

Donor organ shortage is still the major obstacle for the clinical application of hepatocyte transplantation in the treatment of liver diseases. However, generation of hepatocyte-like cells from ...

This article explores a number of frequently asked questions around working with plateable hepatocytes. It also outlines common reasons that hepatocyte plating fails, providing a range of potential ...

In a new study published in the Journal of Hepatology, researchers from the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) show that only 15–20% of hepatocytes in newborn mice—dubbed ...

New MIT research uncovers how high-fat diets push liver cells into a primitive state, elevating cancer risk. Learn how fatty ...

Scientists have warned that high-fat diets can fundamentally reprogram liver cells in ways that make cancer far more likely ...

What am I looking at? This is a single human hepatocyte. Its two nuclei are in blue (1). The other colors in this image are stains of the actin protein and are depth-coded, with red being the closest ...