Vividion Publishes Discovery of First-in-Class KEAP1 Activator, Supporting Ongoing Clinical Program in Oncology

Vividion announces publication on discovery and preclinical study of small molecules activating KEAP1 via a covalent molecular glue to degrade NRF2.
News-Medical.Net on MSN

Euphorbia neriifolia L. extract protects against cardiomyocyte injury and heart failure

Announcing a new publication for Acta Materia Medica journal. Heart failure (HF) remains a major global health challenge with ...
AlphaGalileo

Euphorbia neriifolia L. extract attenuates heart failure by modulating the Nrf2/ROS/HIF-1α signaling pathway

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Nature

Nrf2 is an inhibitor of the Fas pathway as identified by Achilles' Heel Method, a new function-based approach to gene identification in human cells

Here we describe the Achilles' Heel Method (AHM), a new function-based approach for identification of inhibitors of signaling pathways, optimized for human cells. The principle of AHM is the ...
EurekAlert!

A CRISPR-Cas9 based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma: cross-talk of FGF21 and the NRF2 pathway

This study is led by Xiujun Cai (Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine). Professor Xiujun Cai's research team screened the whole genome of ...