The 2025 NFL regular season comes to an end on Sunday, and two playoff berths are still to be determined, with the AFC North and NFC South on the line.

Here are the top betting storylines going into Week 18 of the NFL season, with all odds from BetMGM: How weird is the NFC South? The Buccaneers have lost seven of eight games and are still favored to beat the team in first place of the division. Tampa Bay is a 2.5-point favorite over the Panthers.

Josh Allen, Trevor Lawrence, Drake Maye, Matthew Stafford and Caleb Williams continued building their MVP cases with the regular season winding down.

With Christmas in the books and a calendar flip on the horizon, the NFL turns from velvet red robes to 2026 resolutions.