For decades, Arieh Warshel, USC Distinguished Professor of Chemistry and a 2013 Nobel laureate, has used computer simulations ...

The protein community is awash in data. As of October, the UniProt database of protein sequences had more than 44 million entries. UniProt serves as a clearinghouse for sequences. Researchers who ...

Synthetic biology is a growing field of research that is aiming to create a new kind of organism. Engineering synthetic proteins that can perform simple cellular functions as they would in real life ...

Annotations of enzyme function provide critical starting points for generating and testing biological hypotheses, but the quality of functional annotations is hindered by uncertain assignments for ...

DEAD-box proteins, which are ancient enzymes found in all forms of life, function as recycling "nanopistons." They use chemical energy to clamp down and pry open RNA strands, thereby enabling the ...

Researchers at Helmholtz Munich, the Technical University of Munich and the LMU University Hospital Munich uncovered a ...

High-resolution structures explain the mechanism of human PNPase and provide insights into mutations causing hereditary ...

Cravatt’s strategy for ferreting out new inhibitors for multiple enzymes simultaneously is a good example “of how a strong understanding of enzyme mechanisms can serve as a starting point for studies ...

(Nanowerk News) The National Institutes of Health has awarded Albert Einstein College of Medicine of Yeshiva University a five-year, $10 million grant to study how the motion of atoms on both ...

In a new study, researchers have discovered how an enzyme that plays a key role in cancer development functions. The researchers hope the new knowledge will lead to the design of more precise drugs.

Researchers have identified how a single mutation in the GPX4 enzyme causes neurons to undergo ferroptosis, leading to severe early-onset dementia.