Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. However, in antiplatelet therapy, routine pharmacodynamic ...

Introduction: In the absence of injury, direct interactions between platelets (Plt) and skeletal muscle myoblasts (Mb) are limited. However, ischemic muscle injury increases vascular permeability ...

Inappropriate activation and aggregation of platelets can lead to arterial thrombosis. Thrombin is the most potent platelet agonist that activates human platelets via two PARs (proteinase-activated ...

Vascular smooth muscle cell (VSMC) migration is an important step in the progression and development of vulnerable plaques. Thrombin is involved in both physiological and pathological processes of ...

Previous ArticleA comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants The levels of NETs, activated ...

Protease-activated receptors (PARs) belong to the G protein-coupled receptor (GPCR) family. Compared to other GPCRs, the specificity of the four PARs is the lack of physiologically soluble ligands ...

Activated factor XII can activate factor XI both in plasma 1112 and on activated platelets. 1314 However, deficiency of factor XII is not associated with a bleeding tendency. 15 This led investigators ...

ABSTRACT: A review of modern evidence using Internet resources has identified the Stress Repair Mechanism (SRM) postulated by Hans Selye in 1951. SRM activity regulates thrombin generation to govern ...

ABSTRACT: A review of modern evidence using Internet resources has identified the Stress Repair Mechanism (SRM) postulated by Hans Selye in 1951. SRM activity regulates thrombin generation to govern ...

Protease-activated receptor-1 (PAR1) is a guanine nucleotide-binding (G) protein-coupled receptor that elicits cellular responses to coagulant and anticoagulant proteases. Activation of PAR1 by the ...